ChemInform Abstract: Synthesis and Reactions of Biginelli Compounds. Part 19. X-Ray Structure, Conformational Analysis, Enantioseparation, and Determination of Absolute Configuration of the Mitotic Kinesin Eg5 Inhibitor Monastrol.
May 7, 2018 | Author: Anonymous |
Category: Documents
2000 structure structure (organic substances) K 9000 25 - 031 Synthesis and Reactions of Biginelli Compounds. Part 19. X-Ray Structure, Conformational Analysis, Enantioseparation, and De- termination of Absolute Configuration of the Mitotic Kinesin Eg5 Inhibitor Monastrol. â Computational, X-ray diffraction, and NMR studies show that monastrol (I) is a conformationally mobile heterocyclic system with no clear preference for one of the four distinct conformers. Resolution of the racemate is achieved by direct enantioselective HPLC. The absolute configu- ration of the first eluting (S)-(+)-enantiomer is established by CD spectroscopy. â (KAPPE, C. OLIVER; SHISHKIN, OLEG V.; URAY, GEORG; VERDINO, PETRA; Tetrahedron 56 (2000) 13, 1859-1862; Inst. Chem., Karl Franzens Univ. Graz, A-8010 Graz, Austria; EN) 1
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