Healthcare Professional financial guide to partnership with Pharmenex Biophotonic Scanner 11 12-13.pptx

1. Origin of Pharmanex •15 years in the Pharmaceutical industry •Identified need for quality control and standards in nutritional industry •Co-founded Pharmanex in 1996 •Achieved $50 million/yr in sales •Purchased by Nu Skin Enterprises in 1998 for $135 million 2. GREATEST DISCOVERY OF OUR TIME The new science of epigenetics reveals how the choices you make can change your genes … by John Cloud 3. NU SKIN'S ANTI-AGING RESEARCH AND DEVELOPMENT TEAM is a Blockbuster Brand – $1 Billion in 2 years Over 75 PhD Level Scientists: Botanists, Pharmacognosist, Natural product specialists, Biochemists, Molecular biologists, Pharmacologists, Quality control specialists and Medicinal,analylitical and process chemists, 4. WORLD CLASS SCIENTIFIC ADVISORY BOARD C. Djerassi Stanford Father of oral contraceptives D. Bearrs Huntsman Cancer Center Pioneer in Cancer genetics G. Halperin Pioneer in Immunology H. Wagner Pioneer in Phytomedicine K. Nakanishi Father of Ginko L. Bohlin Pioneer in Natural Products L. Mitscher Pioneer in Green Tea A. Kimball Harvard Dermatologist L. Packer Father of antioxidants M. Kuro-o Discoverer of Klotho aging gene M. Wanner Harvard Dermatologist P. Cox Pioneer in Ethnobotany R. Weindruch Pioneer in Aging Research T. Prolla Pioneer in Aging Research Z. Draelos Duke Dermatologist 5. Frank Johnson, MD • Over 30 years of surgical practice • During this time 18 years in an aesthetic practice • Initiated artificial nutrition program at Winthrop University Hospital • Chair of the Subcommittee on Nutrition at Winthrop University Hospital • Lectured extensively on artificial nutrition • Lectured in Europe, South America and Asia on the use of lasers • Organized and hosted the International Roundtables on Aesthetics • Trained over 1000 physicians on the use of lasers, intense pulsed light and other aesthetic procedures. • Presently working with Nuskin, skin tightening techniques and treating venous disease. 6. THE DISAPPEARING FEES 1975 AND 2011 A 36 YEAR PERIOD 7. THE DISAPPEARING FEES • HERNIA REPAIR • APPENDECTOMY • GALLBLADDER REMOVAL • COLON RESECTION • LIABILITY INSURANCE 1975 2011 2020 • $600. $450. ??? • $585. $500. • $880. $750. • $1250. $1200. • $10,000 $120,000/YEAR 8. STATE OF THE ART WORLD HEADQUARTERS Anti-Aging Innovation Center - $100 MILLION 14-US0513NR 9. 6 S • SELECTION new botanicals: properties and benefits • SOURCE of botanicals • STRUCTURE anaalysis of natural compounds • STANDARDIZATION optimizes the active ingredients of a product • SAFETY avoid microbes , toxins and heavy metals • SUBSTANTIATION documented preclinical and clinical studies published in major international journals 10. • Only validated non-invasive anti-oxidants instrument • Money back guarantee if LifePak or g3 don’t improve anti-oxidant protection • Endorsed by Prof. Lester Packer, UC Berkeley and ―Father of anti-oxidant research‖ Biophotonic Scanner: How do you know whether your supplements work? 11. What Do We Measure? Carotenoid antioxidants in stratum corneum 12. AS YOUR BODY FAT % GOES DOWN | YOUR SCAN SCORE GOES UP How do you know if your supplements are working? 14-US0513NR 13. Effect of Fruit & Vegetable Consumption 21 27,174 29,962 31,138 32,505 0 5,000 10,000 15,000 20,000 25,000 30,000 35,000 40,000 Less than 2 servings 2-3 servings 4-5 servings 6+ servings Mean Scanner Score 14. What is LifePak Nano? A comprehensive nutritional wellness program delivering optimal amounts of essential and semi-essential micro- and macro-nutrients typically lacking in diets, for the support of all body systems and organs for long term health and wellness. 15. The Nanotechnology Difference Pharmanex patent-pending & proprietary process Small nano-nutrients are easily dispersed and absorbed + = Lycopene CHO “Chaperone” Nano- Lycopene 16. LifePak Nano Contains • All 8 forms of natural vitamin E • Buffered vitamin C • Selenium, Copper, Zinc, Manganium • Nano Carotenoids: – as found in 5-10 fruits & vegetables per day • Over 20 Flavonoids: – green tea catechins, quercetin, naringenin, hesperidin, grape seed polyphenols, resveratrol • Alpha lipoic acid 60+ Antioxidants 17. The Nanotechnology Difference pmol/mgprotein γ-cyclodextrin complex 5-fold increase in absorption! Adapted from Craft et al, FASEB Journal. 2005; 19(4): Abstract #281.6, A449. 18. LifePak® Clinical Study Smidt CR, Seidehamel RJ, Devaraj S, Jialal I. FASEB Journal Vol.13 No.4, p.A546, March 1999. LDL Protection Vitamin E Beta-carotene Antioxidant and Cardiovascular Health 19. 18937 19244 0 5000 10000 15000 20000 25000 30000 Male Female Scanner Reading vs. Gender n = 704 n = 666 20. Oxidative stress and Skin Carotenoids 0 10,000 20,000 30,000 40,000 50,000 60,000 Raman Intensity, Counts 0 2.0 4.0 6.0 8.0 Isoprostanes pmol / L UrinaryF2-Isoprostanes(pmol/L) 21. Skin Carotenoids and Plasma Antioxidant Vitamins E and C Raman Intensity, Counts 0 10,000 20,000 30,000 40,000 50,000 60,000 PlasmaAntioxidants(mM) 22. 19890 13030 17600 17591 13056 11593 0 5000 10000 15000 20000 25000 30000 Non- Smokers Smokers (all) Past Smokers < 1/day 1-5/day > 5/day Effect of Smoking 23. Effect of weight on scanner score R² = 0.502 0 5000 10000 15000 20000 25000 30000 35000 40000 45000 30 50 70 90 110 130 150 ScannerScore Weight (kg) 24. Effect of LifePak Supplementation 19950 26858 29463 33173 0 5000 10000 15000 20000 25000 30000 35000 40000 45000 Time (weeks) 0 4 8 12 V.Low|Low|Mod.|High p < 0.01 p < 0.01 Scanner score 25. • Recent paper published in the Journal of Nutrition, 2004: – Carotenoids (blood) are indicator of total antioxidant status – Carotenoids interact with the antioxidant network – Vitamin E (blood) is not a good indicator of antioxidant status Carotenoids Predict Antioxidant Status 26. BIBLIOGRAPHY • JAMA. 2002;287(23):3127-3129. suboptimal intake of some vitamins, above levels causing classic vitamin deficiency, is a risk factor for chronic diseases and common in the general population osteopenia and fractures; and low levels of the antioxidant vitamins (vitamins A, E, and C) may increase risk for several chronic diseases. • Diabetes. 1997 Nov;46(11 Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. • Archives of Internal Medicine Impact of Trace Elements and Vitamin Supplementation on Immunity and Infections in Institutionalized Elderly Patients Low-dose supplementation of zinc and seleniumprovides significant improvement in elderly patients by increasingthe humoral response after vaccination and could have considerablepublic health importance by reducing morbidity from respiratorytract infections. • Nutrition and Metabolism Center, Children's Hospital Oakland Research Institute Bruce N. Ames Optimizing micronutrient intake could have a major effect on the prevention of cancer and other degenerative diseases of aging. Research on delay of the mitochondrial decay of aging • Oxidants, antioxidants, and the degenerative diseases of aging Proc. Nat’l Acad Sci. Division of Biochemistry and Molecular Biology, University of California, Oxidant by-products of normal metabolism cause extensive damage to DNA, protein, and lipid. We argue that this damage (the same as that produced by radiation) is a major contributor to aging and to degenerative diseases of aging such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts. Antioxidant defenses against this damage include ascorbate, tocopherol, and carotenoids. 27. Scientific articles • Smidt, C.R. Ph.D., FACN, Effect of LifePak® Supplementation on Antioxidant Status Using BioPhotonic Raman Spectroscopy. Pharmanex in-house Study. 2002 • Zidichouski, J.A., Poole, S.L., Gellermann, W. Smidt, C.R. (2004) Clinical validation of a novel Raman spectroscopic technology to non- invasively assess carotenoid status in humans. Journal of Am. Coll. Nutr. 23 (5): p.468 . • Zidichouski, J.A., Poole, S.L., Gellermann, W. Smidt, C.R. (2004) Clinical validation of a novel Raman spectroscopic technology to non- invasively assess carotenoid status in humans. Journal of Am. Coll. Nutr. 23 (5): p.468 . • Fiutem J, Zukley L, Geise T, Legowski P, Nguyen V, Dube T, Yount B, Smidt C, Angelopoulos T, Rippe J. Adiposity Negatively Influences Carotenoids and Antioxidant Status in Overweight Individuals. Medicine and Science in Sports and Exercise. 36 (5) Supplement S302, 2004. 28. Pharmanex Clinical Study Report • PHARMANEX CLINICAL STUDY REPORT • February 23, 2000 • EFFECTS OF LIFEPAK® SUPPLEMENTATION ON ANTIOXIDANT STATUS AND LDLOXIDATION • IN HEALTHY NON-SMOKERS • C. R. Smidt,1 PhD, R. J. Seidehamel,2 PhD, S. Devaraj,3 PhD, I. Jialal,3 MD, PhD • 1 Pharmanex Research Institute, Provo, UT; 2 GFI Pharmaceutical Services, Inc., Evansville, IN; • 3 University of California at Davis Medical Center, Sacramento, CA • ABSTRACT • Background: Although there is substantial evidence for antioxidant effects of • individual nutrients, such as vitamins C and E, little research has been done to show • the antioxidant efficacy of nutritionally complete micronutrient supplements. • Objective: This study examined whether a comprehensive multivitamin/mineral • supplement (MVMS; LifePak®) improves antioxidant status and resistance to LDL • oxidation in healthy non-smokers. Methods: In this double-blind, randomized • crossover study, 50 subjects received MVMS and placebo (PL) for 6 weeks with a • 6-week washout period. MVMS provided vitamin C, vitamin E, carotenoids and • flavonoids among other nutrients. Results: MVMS significantly increased serum • concentrations of ascorbic acid (from 68.1 to 94.3 μmol/L) β-carotene (from 335 to • 716 nmol/L), α-carotene (from 77 to 592 nmol/L), and vitamin E (α-tocopherol, • from 20.0 to 36.9 μmol/L), with no changes in PL treatment. MVMS significantly • decreased LDL oxidizability, as the lag time was prolonged (by 17 %), and • oxidation rate was reduced without changes with PL treatment. Conclusions: • MVMS significantly increased serum antioxidants and decreased LDL • oxidizability. Results suggest that MVMS supplementation may have • cardiovascular and antioxidant benefits in healthy non-smokers. 29. JNCI • Study fromBrigham and Women’s Hospital and Harvard reviewed 3055 cases and 3955 control patients 3000 with ER (–) higher carotenoid levels had inhibited growth 30. IN OUR GENES INFLUENCING the way we age in every way 31. ageLOC: a genetic anti-aging approach Gene expression science (ageLOC) provides an innovative anti-aging product platform encompassing both skin care and nutrition 40 32. Does North America have a weight problem? 33. 19851986198719881989199019911992199319941995199619971998199920002001200220032004200520062007200820092010 NO DATA <10% 10%-14% 15%-19% 20%-24% 25%-29% ≥30% Who is going to solve this problem? www.CDC.gov/ 34. Is there a solution? 35. 林書豪身高192cm 體重91kg ，連勝文身 高192cm體重92kg 36. GOAL STARTING WEIGHT But 20-40% of what they lost was lean muscle Less Muscle = Weight Gain THE PROBLEM WITH “DIETING” 37. DIETING GOAL STARTING WEIGHT -YY 38. Omron HBF-514C Body fat% Body mass index (BMI) Skeletal muscle% Visceral fat level Body age Resting metabolism Body weight 39. Introducing a breakthrough weight management and body shaping system, based on highly innovative gene expression science, that unifies your mind and body—for a leaner, younger looking you. 40. M us cle M us cle Metabo lic Burn Metab olic Burn LEAN MUSCLE = METABOLIC ENGINE Traditional Diet: • Lose lean muscle ageLOC TR90: • Maintain more lean muscle Metabolic burn = rate at which body burns calories at rest Fat Muscle Fat Muscle Metabolic Burn Metabolic Burn 41. Leveraging Gene Expression Science To unify body and mind in powerful partnership MIND & BODY MIND BODY 42. • Lactose free • Gluten free • Soy free • Vegetarian proteins • Greens: • Wheat Grass • Alfalfa • Spirulina • Chlorella • Beet Root • Spinach • Barley AGELOC® TR90 GREENSHAKE *Limited availability during the LTO. 43. Simple Eating Plan AGELOC® TR90™ Weight Management and Body Shaping System An advanced weight management system that helps you look leaner and healthier in 90 days. Active Lifestyle Advanced Products 44. Supplement: Jumpstart 1 Non-Shake Healthy Meal Meal Components: • 1 Protein • 1 Grain • 1 Fruit • 1 Vegetable Supplement: Fit 30-60 Grams Protein/Meal (Depending on Body Size)* Protein Source Options: • TR90 Shakes (2 x per day) • Lean Meat, Fish • Dairy, Eggs, Cheese • Beans/Legumes • Nuts, Seeds Supplement: Control/LifePak Snacks Snack Options: • Element Bar • Fruits • Vegetables LIMIT Added sugars and processed foods i.e., crackers, white flour/sugar, chips, sugar sweetened drinks and dressings EATING PLAN 3X A DAY 2X A DAY 1X A DAY *Based upon 90 day Target Body Weight, assuming 2 pounds per week weight loss: Target weight in Kgs X 1.6 = total daily intake in protein grams. Example: Current weight 250 lbs. Target weight in 90 days 226 lbs. 226/2.2 = 103 Kg x 1.6 = 164 grams of protein per day recommended, divided evenly three times per day, ~55 g protein/meal: Breakfast, Lunch and Dinner. 45. * Limited GREENSHAKE option also available. AGELOC® TR90 LTO KIT 46. PROMISING CLINICAL RESULTS • Significant decrease in body weight related to fat loss in both genders • Visible decrease in stomach, thigh & calf measurements • Reduced cravings • Hunger decreased at the end of the study Money Back guarantee for inches lost 47. JEFFREY H. BELMONT M.D. SUNY DOWNSTATE MEDICAL M.D. 1979 BROOKDALE HOSPITAL CENTER GENERAL SURGERY 1980 NY EYE & EAR INFIRMARY – OTOLARYNGOLOGY HEAD AND NECK SURGERY 1983 NY MEDICAL COLLEGE & LENOX HILL HOSIPITAL FELLOWSHIP HEAD & NECK SURGERY 1984 PRIVATE PRACTICE NEW YORK CITY AND STAFF SURGEON NY EYE AND EAR INFIRMARY 20+ YEARS CURRENT – MANAGEMENT PERSONAL HOLDINGS/ACCREDITED INVESTOR, SELF- EMPLOYED NUSIN/PHARMANEX , DOWNHILL SKIING 48. Now Let’s talk Dollars and sense 49. - TIME - MONEY $ + TIME - MONEY $ - TIME + MONEY $ + TIME + MONEY $$$$ 50. BIO$CAN WELLNE$$ PROGRAM 51. COMES WITH A BUILT-IN “REVENUE CREATION SWITCH” 3 SETTINGS: SMALL MEDIUM LARGE 52. Program Benefits • Earn from every scan • Build residual income through supplements • Receive new patient referrals •MONITORING SYSTEM 53. ROI (Return on Investment) • Typical ROI for new equipment 3 to 5 years Bio Scan ROI: • 5 to 20 times investment annually 54. Initial Investment $2,750 initial inventory $ 500 deposit $ 80 Shipping $ 3,330 + Tax Approximately $3,500 55. Initial Investment  Three packs of G-3- 6 bottles  Nine Life-Pak Nanos  Two Life Paks  100 scan portfolios  Two Vitox  600 testing cards 56. Scanning Revenue Scan 5 patients per day 100 scans per month x $25 = $2500 per month $30,000 per year 8.5 x ROI 57. Testing Revenue Test 2 or 3 patients per day 50 tests per month x $20 = $1000 per month $12,000 per year 3.5 x ROI 58. Supplement Revenue 100 Patients purchasing $100 per month ADR = $10,000 per month sales Volume Free Scanner lease (starts at 5K volume) $ 30,000 residual income annually + 30,000 scanning fees $ 60,000 annual income 17 x ROI 59. Supplement Revenue 50 Patients purchasing $100 per month ADR = $5,000 per month sales Volume Free BioPhotonic Scanner lease $ 13,200 residual income annually + 12,000 testing fees $ 25,200 annual income 7.5 x ROI 60. Patient Participation • 10% of your files will want to increase their Antioxidants and improve their health The National average shows: 100 patients = $30,000 yr. + Scan fees 300 patients = $90,000 yr. + Scan fees Residual income that you take into retirement! 61. The Lease 36 months @ $209 per month HOW TO GET A FREE LEASE: Add 5 patients to ADR in any month Have $5,000 or more in sales volume Healthcare Practitioners who work the program NEVER make a lease payment 62. Program Benefits • Healthier Patients • Earn a minimum of $12,000/year by testing in your office • Build residual income through supplements to take into retirement • Free Scanner lease • High Tech Cutting Edge Practice • Receive new patient referrals • Extraordinary Return on Investment 63. YOU CAN OFFER: • ESTHETIC PROGRAM • GLOBAL EXPANSION - 53 MARKETS + • AGELOC SCIENCE PROGRAM WITH GENETICALLY BASED ANTIAGING PRODUCT LINES • INCLUDING REVOLUTIONARY WEIGHT MANAGEMENT AND BODY RESHAPING SYSTEM 64. HCP REFERRAL PROGRAM For Hcp’s without 20+ flow and ENTREPRENEURS 65. $60,000 EVERY YR ? * • 10 HCP’S (each with $5000 ie. 50 clients) • 10% of $5000/mo = $500/mo per/HCP • * RESIDUAL 66. 10% * • 4 HCPS ($5000/month vol) = $24,000/yr • 10 “ = $60,000/yr • 100 “ = $600,000/yr • * On DIRECT referrals • * RESIDUAL 67. START TODAY We will assist you and train your staff on how to implement the Bio Scan Wellness Program. White Papers, clinical trials and studies on the Scanner and the supplements will be made available to you upon request. 68. THE END 69. Average lifetime Earnings 91,000 hours of lifetime work High School Graduate $1,000,000 College Graduate $2,000,000 Professional Degree $3,000,000 Taxes Housing Transportations Food & Entertainment 70. 2012 AVERAGE MONTHLY COMMISSIONS EX $401 1 $801 4 $1,392 8 $10,532 12 $51,436 6 14-US0513NR ANNUALIZED1 1- Average Monthly Commissions Multiplied by 12 2-These averages are calculated by taking the average of the total monthly distributor/executive payee count at each level and dividing it by the total number of monthly Active Distributors Generating meaningful compensation as a Distributor requires considerable time, effort and commitment. There are no guarantees of financial success. These figures do not represent a Distributor’s profit, as they do not consider expenses incurred by a Distributor in the promotion of his/her business and do not include retail markup income success. The average commission paid to U.S. Active Distributors each month was $133.92. The average monthly commission paid to U.S. Active Distributors who earned a commission check was $1,010.26. On a monthly basis, an average of 13.26% of U.S. Active Distributors earned a commission check. Active Distributors represented an average of 39.91% of total distributors.* *Total distributors includes all distributor accounts currently on file, irrespective of whether they have been active (e.g. purchasing products etc.). It does not include preferred customers. 2 $2,720 $4,812 $9,612 $16,704 $126,384 $617,232$62,892$32,640 $5,241 For information on the average percentage of distributors at each level see the table below MONTHLY 71. Trading “100% of me” for money Jobs / RE Pro’s / Reps SBO’s / Teachers Work 40 hours x 50 weeks 2,000 hours/year x 45 years 90,000 hours Linear Income Takes a Lifetime 95% Broke Died Still Working 43% of Americans have LESS THAN $10,000 in Savings for Retirement. 72. Trading “100% of me” for money Jobs / RE Pro’s / Reps SBO’s / Teachers Work 40 hours x 50 weeks 2,000 hours/year x 45 years 90,000 hours Building a Network teach 5 to teach 5 each 25 125 625 3,125 15,625 Approx. 20,000 x 4.5 hrs 90,000 hours Linear Income Leveraged Income Takes a Lifetime Happens every week 73. WHY NOT ? WHAT IF ? 74. AGELOC® TR90 JUMPSTART The perfect push to get you primed and ready for success. By resetting your body’s balance, you can see the beginnings of success in just 15 days—and experience all the motivation that comes along with it. * This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. 75. AGELOC® TR90 CONTROL A key component to make it easier to stay focused on the path to success. * This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. 76. AGELOC® TR90 FIT A great way to get your body back on track with optimum weight management. * This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. 77. AGELOC® TR90 TRIMSHAKE An easy and delicious solution that removes the guesswork—giving you the ideal protein you need while helping you control calories. * This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. 78. Cravings Mood Willpower Energy DIETING PROBLEMS 79. WHAT’S THE SOLUTION? TRANSFORM KEEP THE MUSCLE LOSE THE FAT 80. OR ARE YOU SKINNY FAT? 81. Dress Size Pants Size Inches Body Fat % Success is not just the scale, it’s… 82. DON’T JUST LOSE WEIGHT, TRANSFORM INTO A HEALTHY, FIT YOU! 83. MUSCLE = A LEAN, TONED, HEALTHIER YOU 84. ACTIVE LIFESTYLE Let’s Get Moving! Strive for moderate activity a minimum of 30 minutes, 3 times a week. 85. • Our Science, Your guarantee – Quality – Innovation – Safety – Substantiated claims • R&D engine – Multi disciplinary team of 75 scientists 6S Quality Process Selection; Sourcing; Standardization; Safety; Structure; Substantiation USA CHINA 86. Dr. Ching Chen Medical School: New York College of Osteopathic Medicine, Old Westbury, NY Residency Training: physical medicine and rehabilitation @ Kingsbrook Jewish Medical Center, Brooklyn Additional Training: Structural Acupuncture made for Physicians, Harvard Medical School In private practice 87. THE ROAD TO FINANCIAL FREEDOM